If you are counting players, the destiny universe would kick the borderlands universes ass. Since destiny is technically an mmo having ten thousand guardians showing up at claptrap's front door with fully maxed Ghorns is an unfair fight. There are more than enough guardians to fight a single player with some varied AIs and hold back all the darkness forces. It is most likely that the darkness forces especially the Cabal would be aggravated by the borderlands forces for storming in. If the borderlands forces pushed on our solar system, they would be bombarded with multiple forces from Mars, Venus, the moon, the reef and spout two thousand guardians right off the bat. If guardians went to go attack Pandora, the Cabal and Fallen would have to be handled first as they would not be able to cooperate with each other and the guardians. But after that it would just be an unfair beat up because as there would be no darkness zones on pandora or the moon. The re-spawn time for all the ten thousand guardians would be 5 seconds... Not fair. However if guardians and players are not part of the picture, borderlands would have a huge advantage with the organization of the armies. The tower does not have an army as far as I can tell. No fleet, horrible weapons, only a couple generals and some robots. I'm sure they would be able to send some citizens of age into war from the city, but they would be handling low level weapons from the gun smith, and this is EvE so the attack would matter. The city would probably try to call on the reef for help which I believe would reply positive considering the circumstances. destiny enemy types would not be able to make an organized defence with each other. Unlike the borderlands enemy types which would be able to get along to fight the destiny universe as a common enemy. The Borderlands universe has a space fleet consisting of massive cruisers, battleships, and fighters. They have multiple generals and powerful machinery and bosses. If the borderlands universe advances on the destiny universe and picked the planets off one by one. I think it would be a win.