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Not sure what this is in regards to, if you are talking about strikes or raids or just missions in general. There are really only two settings for things in TTK, easy or hard. unless you are looking for a specific drop that only occurs on hard, you are better off doing easy. You can grind through easy quickly and move on to more missions. Hard mode usually doesn't net you anything better unless you are talking about raids. In which case, Crux of Crota only drops (10% chance) on Hard Crota's End, and King's Fall hard gets you a [b]chance[/b] at drops over 310.