I find I run out of ammo too quickly and green ammo drops aren't frequent enough. All of the shotguns I've used have less ammo reserves than fusion rifles and fusion rifles (especially with armor piercing) have more potential to take out multiple enemies.
This is on top of what most other people have said (short range equals dead most of the time).
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Yeah, wish they would buff the ammo capacity of shotguns. Especialy a great gun like Secret Handshake suffers from this. :/