What game ending gave you a case of the feels? For me it would be The Walking Dead: Season 1's ending. I won't lie, I cried.
So what about you? What game made you cry?
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Possibly the only one sadder then metroid prime, would have to be legend of Zelda. Link goes through all that, and Zelda wont even give the poor bastard so much as a thank you bj. At least Minda transformed him into a wolf. :)