Mine is "How do you win?" Or "what's the point of the game" or when I die "wow you suck"
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If my wife sees me playing the same game for a while, especially one that you can continue to play after the main story (Diablo 3, any AC, WoW/any MMORPG, etc), she asks "Have you won yet? Why play a game you can't [i]beat[/i]?" It's not that she questions playing games, she just prefers ones that are more old school, with levels you beat, an ending and final score. I prefer growing and developing characters, I like leveling up instead of just beating levels/stages. I like collecting a menagerie of powerful items and equipment! She calls it playing "dress-up" like little girls with their dollies >.>