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Which conflict? The one in 2557, or the human-Forerunner wars of 110,000 BCE?
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The one 100.000 BC
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Threatened by the expansion of the Flood, humanity and the San 'Shyuum fled fled away from their territory, expanding into Forerunner territory, taking their worlds and resources while destroying any that they found the Flood on. This extreme aggression forced the Forerunners to respond with the full might of the Warrior-Servants.
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Because The Didact told them to.