A friend of mine had this idea of how to use an ammo synthesis without navigating through the "pause" menu.
When you are out of ammo for a specific weapon, you could press and hold the fire button for ~3 seconds and it would automatically use an ammo synthesis for that type of weapon.
This method wouldn't interact poorly with any other action since the fire button is effectively useless when a weapon with no ammo is currently equipped.
Thoughts?
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In another thread I (and others) had the idea to just hold the reload button a while longer (when all ammo is depleted). DeeJ saw that and said he will play it through to the devs...