Not sure if you all have looked any of this up so I though I'd post it here. Fallen - headshots Vex - aim for the glowing part of their body (ex: stomach for goblins, eye for harpy/hydra, etc.) Hive - headshots (stomach for Photogh) Cabal - headshots Shields: Match the color with the type of damage. Purple - use void damage Orange - use solar damage Blue - use arc damage Vex minotar - No weak spots. Bring the shield down and destroy the head so the shields stay down. When I find more I'll add on to this, but so far this should help for missions/raiding/strike.