I love and own a copy of Cards Against Humanity, will soon be getting a set of two decks for Adventure Time's Card Wars and backed Legendary Showdown on kickstarter which is based on the Dr.McNinja universe. Really loved Yu-gi-oh when I was a kid but fell out of it, pokemon was neat too. Of course there's also regular card games, I learned how to play cribbage today
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I find myself really enjoying Magic The Gathering. My only complaint is it can be hard to get a good zombie deck working. Although I have two and they both decimate the competition.