It can be anything really, like for me, The first thing I will do is go to Grove Street and Visit CJ's hood just to take in the memories from San Andreas.
What about the Community I wonder? Please comment below on what would be the first thing you will do in GTA V?
Edit : I don't mean buying and installing in your HDD, like after the first mission where you could Free Roam
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Kill a hooker, and then do cocaine off her dead body... Then I will go pick up the game and play it.