Some of them can be frustrating as hell. The torture button mash in MGS1 and Peace Walker was hell on my fingers.
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Some of the button mash scenes for the Walking Dead were pretty difficult.
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it isn't hard, but Asura's Wrath has some of the more "fun" QTE's, and follow up events. Hardest....erm...none.
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That crawling scene at the end of MGS4.
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I remember some button-mashing required to tear people off of the turrets in Marvel Ultimate Alliance. As a kid, I found it impossible to press B that damn fast, and it was a goddamn requirement. You couldn't damage him without pressing B at the speed of light
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God of War II: final boss fight was obnoxious in the time it gave you to react. The only way I could finish it was the pause/unpause method.
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Peace Walker. Halo 4. That game has the hardest quick time events and button mashers I have ever seen in a game. That final boss was a bitch.
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Tug of War type fights in mario party on N64. Rotating the joystic real fast using your palm caused a ton of blisters.
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Edited by Trollheim: 6/8/2013 3:28:54 PMSome of the Resident Evil quick times. If you aren't already waiting to hit the correct button on higher difficulties, you'll immediately die. I admittedly also failed some Peacewalker quick times. Oh, and this thread wouldn't be complete without Mario Party 1's tug-o-war. **** that shit up the ass, hard. I couldn't get 100% completion on mini-game island because of it.