There have been several interesting takes on a talent tree or skill progression in gaming over the last few years.
Path of exile comes to mind for a long term player progression.
The instant changeability of the Diablo III system
The 3 tree version that WoW uses
What would you like to see, and how would you like it implemented?
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I think Skyrim has the best progression system and I think you should work work towards class specific specializations. Example, a hunter could become a full on Sniper, a saboteur who relies on preemptive thinking and ambushes, an infiltrator who relies on stealth and hit-and-run tactics, or an assassin who specializes in attacking a singular enemy with great damage. I think there should be no perks and that abilities should be based on the equipment used. If you wanted a active camo type ability you would have to use a piece of armor that achieves that effect. Specializations would give you passive boosts like a Sniper would have increased critical point damage, a saboteur would have a bonus suprise attack damage, an assassin would have increased damage when focused on a single tareget, and an infiltrator would have increased stealth.