There have been several interesting takes on a talent tree or skill progression in gaming over the last few years.
Path of exile comes to mind for a long term player progression.
The instant changeability of the Diablo III system
The 3 tree version that WoW uses
What would you like to see, and how would you like it implemented?
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Mass Effect 1's mixed with Mass Effect 3's. Or mixed with Fallout's or Skyrim's.