There have been several interesting takes on a talent tree or skill progression in gaming over the last few years.
Path of exile comes to mind for a long term player progression.
The instant changeability of the Diablo III system
The 3 tree version that WoW uses
What would you like to see, and how would you like it implemented?
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I'll list my hopes for the skill tree: - In-Depth. I want the ability to build my character in a way that PERFECTLY suits my playstyle. Somewhat of a combination of Mass Effect and Skyrim. - Co-Op only. Competitive should be fair ground for players new and old. (Also eliminates the "Best Build" mentality) - Effects more than combat. Abilities that effect my vehicular performance as well as maybe crafting/weapon modding. - Respec. This isn't exactly a hope, but it'll definietly be there. This is the kind of thing that would be permanent, but provides an opportunity for Bungie to have a micro transaction that would let you respec (We all know Destiny will have microtransactions) - Friendly GUI. Streamlined and easy to navigate. That's pretty much it. Everything else I want as been aforementioned.