There have been several interesting takes on a talent tree or skill progression in gaming over the last few years.
Path of exile comes to mind for a long term player progression.
The instant changeability of the Diablo III system
The 3 tree version that WoW uses
What would you like to see, and how would you like it implemented?
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I'm not certain that Destiny is going to be nearly as RPG-like as some of you make it out to be. But for the sake of discussion, what sort of specific skills would you expect players to be able to choose?