I've seen hackers in virtual person in TF2 on a Valve server. Permanent crits and a text spamming script. I've also seen infinite jumps and invulnerability in Metroid Prime Hunters, and modded weapons which crashed the game in the first Borderlands. Resident Evil 5 also has some glitches and hacks for infinite healing items and ridiculous weapons.
Wut bout you, Flood? What games and what hacks have you seen?
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I've played against cheaters in a variety of games and honestly, I've never understood the appeal. It takes away the satisfaction of winning by breaking the game and cheating against others. I guess some people just like to watch the world burn. In those games with really evident cheating, I just don't care much. But, I honestly want to gripe against those using modified controllers. Talk about wrecking an even playing field and being difficult to catch. Those piss me off.