I've always thought about this while playing, what is the strongest weapon? We have weapons like ruinous effigy that can turn people into volatile spheres. Then we have touch of malice, which was made from the corpse of a hive god. And to top it all of we have bad juju, which is said to be capable of destroying existence itself. With weapons like these I really wonder how we haven't killed the witness already.
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Technically graviton Lance. It fires mini blackholes. If the game was true to lore then it should 1 shot anything and possibly destroy existence since blackholes tend to grow and expand. As I recall a blackhole the size of a baseball would be enough to destroy the earth.