I am excluding Tactics, BoS, and Fallout 76 since they are either not part of the main series of single player rpgs or are canonically dubious.
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I liked the darker setting of three, the gameplay of Vegas, and the companions of 4. Town malinger was cool until your defenses for what ever -blam!-ing reason didn’t stop co start kidnappings. In later play through’s I simply refused to establish settlements because the upkeep was annoying. It’s not like there are people living there that should be able to maintain it themselves. I hated micromanaging.