(Can be in D1 or D2)
Mine just happened yesterday while patrolling the Moon.
I killed a Nightmare Ogre point-blank with a grenade launcher (blowing myself up in the process) and he dropped an exotic.
It was Monte Carlo. I almost died of laughter.
So I guess if you want an exotic, just perform a ritual sacrifice.
English
#destiny2
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Best loot drops I've ever seen was for a teammate on VoG (d1); he managed to get fate bringer, found verdict*, gjallerhorn (his first drop) and a vex mythoclast all in his very first run! * (shotgun, I might be getting the name confused with something else??)