Personally, I think the series has really worn out Rapture, and Columbia always felt a bit 1-dimensional to me, so a new location seems best.
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Edited by Vgnut: 7/2/2017 9:09:00 PMI would want to see something new. With that said 2K closing Irrational signals to me that they are moving on from Bioshock games. 2 and Infinite just didn't capture the success of the first game.