I just finished playing the Pre-Sequel (TVHM) and was thinking of how 3 is going to work. I personally would love to be able to play as either of the Sirens again. I've always focused on using elements in the Borderlands games.
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The only playable character I can stand in any Borderlands game is Gaige, so.. If they can make someone who's not annoying in personality, and has a fun playstyle, then new characters I guess. Without 300 Stacks of Anarchy at all times, though, I'm not sure I'll be able to get into it..