I switch weapons all the time. Every strike is different. After a few runs you know exactly which enemy spawn. Its all about ammo management. For some bossfights a fusion rifle is good. Sometimes a sniper. I only eqip a sniper if i know that its good for the next encounter and need to collect ammo. For the shielded enemys from this weeks strike use a weapon with explosiv rounds. Extra damage on the shield. Smallarms buff does the rest. Running through it with zhalo is just boring.