Who would win?
Im betting 6. His/her/its "hyper-lethal" skills would make up for his/her/its older armour i bet.
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This would be a closer fight than most people are giving Locke credit for. Six has superior training, enhancements, and experience, but Locke's power armor is leaps and bounds above Six's. Enough so that Si's superior enhancements would be nullified. Six would win, but only because of experience.