Destiny would have the upper hand at first, but eventually half of all guardians would desert or destroy their ghosts and commit suicide from how monotonous and repetitive their offensive actions get. With essentially no command structure aside from three people who never leave the Tower, faith in the cause would die out and all that's left would be the 'earners' and level 40 elitists. Halo would triumph but would eventually stagnate, due to a lack of originality in new content and the wannabe "Spartan" IV program recruiting nothing but jocks and Sarah Palmer jackoffs. Plus with ONI trying to control everything, what with carrying out an assassination attempt on Dr. Halsey and fueling the Sangheili civil war, the unity forged in the fires of the war against the Covenant would disintegrate and man would eventually destroy itself or end up on the wrong end of the Arbiter's rage.
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Guardians are notorious for seeking out power and fame. If there were still spartans to kill and armor to haphazardly glue together then they certainly wouldn't become bored and commit suicide. The UNSC would not stagnate, your statement about spartan IV's are false. In this battle we have to assume that all forces and factions would work together against the other game/universe. So ONI driving apart the treaties (which almost certainly wouldn't happen by itself) can not happen. Also all factions are involved so we must include the city, the reef, the fallen, the hive, the vex, the cabal, the warminds, the nine, the covenant, the ex-covenant, the rest of the UNSC, the forerunners, the flood/precursors, as well as the spartans, ONI, the guardians, and the vanguard like you mentioned.
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Edited by Edcub One: 2/19/2016 7:25:23 PMThe Precursors would crush Destiny with ease with reality warping beyond anything destiny has shown.