Prove me wrong. I'm a lore expert on Destiny, so odds are I can refute any argument you provide that favors Destiny. Vegeta and Goku would beat the entire Destiny universe in a fight.
Lets also assume they know the mechanics for the VoG and Crota's End.
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They could just systemically blow up every planet opposing them, and Goku can oneshot any force of the darkness with Spirit Bomb. Oryx could take him, I guess, or maybe some more Elder Hive have greater powers than them, but yeah. This one probably goes to DBZ.