I just got 100% on Fallout 3 and I love the game to death but it's so broken and full of bugs. There's terrible input lag, crashing, freezing and frame rate problems. If Fallout 4 is like this...God help us all.
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It all will depend on if it is going to be 32 or 64 bit. Previous Bethesda games have always been 32 bit exclusively which means the dreaded 3.1gb memory limit; anything more and you CTD. Hopefully they release a 64 bit version alongside 32 bit version, or perhaps even go 64-bit exclusively, there is no reason to even make 32 bit versions of games anymore.