I just got 100% on Fallout 3 and I love the game to death but it's so broken and full of bugs. There's terrible input lag, crashing, freezing and frame rate problems. If Fallout 4 is like this...God help us all.
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Bethesda said something about learning about glitches from their past games, including Fallout 3 and Skyrim, and using that info to make Fallout 4 less buggy. If that's true, I expect great things. Even if it's just a marketing ploy, the game will probably still be more polished that Fallout 3.