I mean, I can take a shot at explaining the difference, if you really want to, and this is coming from a former Catholic. There are something like, what, 1.2 billion Catholics in the world? In the Western world, Catholics and Christians in general are not exactly a marginalized or maligned group, and generally occupy positions of respect and power. If you were a Catholic/Christian in Syria or somewhere like that, this would be a different story... Transgender individuals, on the other hand, make up an extremely small portion of the population wherever you go. They are largely maligned and misunderstood. Up until very, very recently, a transgender individual couldn't even "come out" as such. Even now, doing so puts them in extreme danger. In the United States, depending on where you live, discrimination against transgender individuals is even permissible under the law. So, no, it's not really the same. It's called "punching down." Now, I think OP is overreacting, but I also don't find anything funny about North's joke, nor jokes about transgender individuals in general.