My fireteam and I (I am Venkman, my partners are Ray and Egon) have discovered a simple way to take out that psychotic "Omni-Ghoul" no Gjally needed. This strategy however does involve the Proton Pack. Equip it before you get to Omnigul. Because Omnigul is supposed to be destroyed, you must use a method called "crossing the streams" everyone must and the beam directly at her, making sure that the beams from each individual proton pack collide with one another. That's it! We came, we saw, and we kicked it's ass in less than 30 seconds. If you need any help with this method, you know who to call ;)
P.S. If anyone needs any professional assistance with this horrific entity, call 1-800-NO-GHOST. we are available to help. We ain't afraid of no ghosts!
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Simply kill the trash, communicate with your team when everyone is ready to focus fire on her. When she screams, run for cover then rinse and repeat till she is dead. Does help to have someone setup to take down her shield no matter what burn is active. She is a marathon not a sprint. Only concern with the trash you should have will be the knight that's is on the stairs straight ahead of you from the safety room. And of course exploding thrall.