Not sure if I should have omitted The Last Word, Thorn, Hawkmoon, etc. But one gun per game seems fair.
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I've used 3 of those. Halo CE pistols. (Magnum & Plasma) Halo: Reach pistols. (Magnum & Plasma) And Golden Gun.. In one of the Goldeneyes. CE wins. Particularly the Plasma pistol. It's a good weapon against everything but vehicles in that game.. At least.. So far. Haven't beaten it, yet. The Magnum was good against everything, including vehicles, but wasn't quite as good against most things. Yes Golden Gun was an instant kill, but it also only had 3 shots.