Who knows. We've never seen the Precursors in a wibbly-wobbly situation before (I bet they may stabilize the 'verse, and Forerunners invent a giant space hoover?)...
Then the Reapers may still live by sneaking about and nudging people and gods to do their bidding without knowing...
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The Chaos God's are omnipresent in the warp. A Lord of Change would probably be enough to wipe out most of the reaper fleet.
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Then again, Reaper Logic may irritate Chaos as a majority to the point where they end up among them, or worse, or better.
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The reapers would more than likely get corrupted.
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Not even the chaos gods would want to look upoun them, for they become that which is feared. That which is inevitable. Death in it's purest form. Their newer human-Reaper would literally resemble the Reaper (one with a scythe).
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You do realize they've destroyed multiple universes in their entirety? I don't think a single galaxy is really going to faze them.
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Bugger.