Prove me wrong. I'm a lore expert on Destiny, so odds are I can refute any argument you provide that favors Destiny. Vegeta and Goku would beat the entire Destiny universe in a fight.
Lets also assume they know the mechanics for the VoG and Crota's End.
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"Power levels are bullshit." And that is the argument. We get space magic, they have space magic and if this were to occur, the "power levels are bullshit" card would put them on the same level. Guardians have no power levels (invisihunters are invisible) guardians weild a different kind of power that the saiyens couldn't master, and so, we'd basically be fighting against Beams with aoe damage, super damage bullets and unbreakable bunker shields. And this is just guardians. Atheon can pause them and spawn enough oracles to fit in vegetas ego, Crota can only be killed by his sword, so, if he's standing there next to the guardians, without his hive knights, there's no sword to weild. The cabal blow up planets and moons and the fallen have Randal the Vandal. When we compare the numbers, there's more than 12 million guardians, unlimited hive, vex, fallen, cabal VS 2 saiyens, one of which has the monkey form, the other of which is now a super saiyen God according to the latest movies as far as I know. Thing is, vegeta and goku need the dragon shenron to revive them if they die, guardians can revive each other. [spoiler]only real way this is unfair and that the saiyens win no problem is to just wish the destiny universe out of existence XD[/spoiler]