Who would it be? I would personally pick Wheatley from Portal 2. While kinda a screw-up, he's frickin hilarious.
Edit: Just to clarify, I meant like an artificial intelligence, a machine.
Edit: Cortana seems to be the favorite here (no surprise).
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Edited by Neno is drunk: 6/5/2015 10:03:53 PMCortana, she talks like a regular person. Reminds me of old school AI's in older video games. Like the suit from legacy of time