This includes fantasy and sci-fi.
My choice is the Combine.
A multi-universal species from half-life so absolutely immense and powerful that they reverse-engineered earth's technology, upgraded far beyond human ability, brainwashed some humans and had them invade themselves. They did this and stomped all resistance within 7 hours. This was done by a backwater lesser combine city mind you.
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Dragons from Elder Scrolls. Because holy shit! Even the freaking Deadra are afraid of those guys. And because there is no Dragonborn IRL there is absolutely no way to stop them.