Random question: evolution is basically an organism changing slowly by (insert factor). It's new information introduced or at least refined information introduced into the DNA which is passed on. Bacteria does this very well, as seen in MDRO. My question is this, how does the organism know how to evolve/mutate? I thought that an extremely high percentage of all mutations are harmful or unproductive? The odds of a cell mutating in a positive way, then passing that new information on without the bodies defense immune system killing it off is extremely low correct? I mean we're not talking about one organism that got lucky, across the board organisms mutated and there immune systems either sucked or were advanced enough to not kill off all the "new" strange cells? This would put them way beyond us. Also bacteria that develops immunity to antibiotics, I thought this was due to the denature or breakdown of proteins? Ex: antibiotics kill bacteria in many ways, some bind to a protein and kill it. It's already been shown that antibiotics can bind to bacteria through a specific protein (let's say A) and not succeed in killing the bacteria but does succeed in destroying the protein A. This half killed bacteria can still replicate but does not replicate protein A because it was damaged. The new bacteria does not have protein A, therefore the antibiotics cannot bind. New bacteria is immune to that antibiotic now. Given this is one example with one antibiotic, but this is not evolution is it? New information was not gained, it was lost. The immunity was caused by the antibiotics not the bacteria. I'm just curious, and apologize if I said something stupid.