Destiny. As a huge Borderlands fan, I can say for certain that the Borderlands universe wouldn't stand a chance against the Destiny universe. With Destiny, you have: The Fallen, a race with several different factions all apparently extremely good at war even without any intel, even going so far as successfully invading the Hellmouth (although they [i]were[/i] stopped by Guardians, but that's besides the point). The Hive, a huge race of undead warriors with literal gods on their side. The Vex, an army of time-traveling, seemingly immortal death bots. And the Cabal, a brutal, war centric race that are capable of wiping out entire planets. Aside from the enemies, we have the Guardians, a massive group of very well trained soldiers with a wide range of skills and abilities. They have been by far the best line of defense Earth has ever seen. Now with Borderlands, you have: Hyperion, a super corrupt company with it's head so far up its own ass it likely couldn't be bothered to help anyone fight the Destiny universe. Dahl, a company apparently incompetent enough to allow a large portion of their military to break off, go batshit insane, and nearly destroy an entire colonized moon due to the ramblings of a particularly crazy woman. Jakobs, what appears to be the only competent company in the entirety of Borderlands, making very effective guns and not getting into any real trouble. Tourge, a company that, while it does make good weapons, has a kind of stupid CEO that will likely cause the company to fail at some point in the future. S&S Munitions, a company that gets put out of business by mere bandits cobbling together weapons with spare parts. Atlas, a company that goes under the moment Hyperion gains power. The the wildlife of Pandora + Elphis, which, while it could cause problems for the Destiny universe, probably won't be a big enough problem. The Eridians, an alien race shrouded in mystery (though from what we've seen, they seem extremely powerful). And finally, the Vault Hunters. While they're all incredibly effective warriors, their numbers pale in comparison to the Guardians. Overall, I feel that the Destiny universe has way too many advantages over the Borderlands universe for me to consider a win from Borderlands.