I think the show is based after episode three and before episode well four coz c3-po and r2 are in the empire for a small amount of time, because this show is telling the story of how the rebellion started (leaving out how the force unleashed sais it)
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Also, I dont think Force Unleashed is official canon. might be, but I dont think so.
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That doesnt explain how the inquisitor is alive. The rule of two says he shouldnt exist.