I'll start:
1. People who throw perfectly fine food away
Your turn!
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Someone who is a [i]reaaaaaally[/i] intolerant and close minded jackass. I can be friends with just about anyone, regardless of their manners, lifestyle, creed, beliefs or anything like that. But if they lack basic human decency towards others, or take pleasure in harming other people/creatures - Yeah, not going to happen.