If you are a guy, that means you would be having sex with someone who used to have a penis, and then surgically turned it into a vagina.
If a girl, you would be having sex with someone who surgically got a penis attached to them.
Would you have sex with this person for a one night stand?
How would you feel if you were in a long relationship with them beforehand, and then one day told you this. after you've already had sex? Would you be mad?
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It depends. If I loved someone very very much before/after it happened and I didn't know and THEN found out, I'd be a little mad they lied to me or something but I mean... I don't know. If its a girl who I found out used to be a guy... I don't think I'd mind.