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I mean he did regenerate himself from a drop of blood once. But then again a Death Star blast would probably vaporize him, leaving nothing behind. Unless adamantium can withstand a blast like that, he would be toast.
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He was buffed at that time. (It's his 3rd point) https://www.bungie.net/en-us/Forum/Post/196181264/0/0
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Yeah if nothing is left to regenerate then he's toast