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He can't regen if he is disintegrated.
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Not if there no cell left remember the two planets that collided killed him and his family.
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Yes but those are two planets and the Death Star is about the size of a moon if I recall.
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Well the death star fire high focus plasma beams right? Heated high enough should vaporized him.
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I believe what they are getting at is that if Mr. Pool takes a direct hit from the death star beam, it will disintegrate all of his cells. No cells= nothing to regenerate from, there was an instance where Deadpool regenerates from one drop of blood one time, but I could be mistaken. [spoiler]No cells- No regeneration [/spoiler]